Protein ubiquitylation is a post-translational modification (PTM) process that covalently
modifies a protein substrate with either mono-ubiquitin moieties or poly-ubiquitin chains …

Ubiquitin (Ub) is often considered a structurally conserved protein. Ubiquitination plays a
prominent role in the regulation of physiological pathways. Since the first mention of Ub in …

Lower back pain, a leading cause of disability worldwide, is associated with intervertebral
disc degeneration (IDD) in approximately 40% of cases. Although nucleus pulposus (NP) …

Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and
pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely …

Functional consequences of protein ubiquitination have gone far beyond the degradation
regulation as was initially imagined during its discovery 40 years back. The state-of-the-art …

Introduction Spinal cord injury (SCI) is a severely disabling disease. Hyperactivation of
neuroinflammation is one of the main pathophysiological features of secondary SCI, with …

Neuroblastoma (NB) is the most common type of extracranial solid tumors in children.
Despite the advancements in treatment strategies over the past years, the overall survival …

Abstract The Ubiquitin Proteasome System (UPS) stands as a cornerstone in the realm of
cellular biology, orchestrating the regulated degradation of proteins essential for cellular …

Ubiquitin modification is one of the important posttranslational modifications (PTMs) that
involves the covalent attachment of a protein called ubiquitin to a lysine residue of a target …