Rho GTPases are molecular switches that control a wide variety of signal transduction
pathways in all eukaryotic cells. They are known principally for their pivotal role in regulating …

Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR)
signals to make crucial cell-fate decisions at several checkpoints during their development …

▪ Abstract Cells of the immune system carry out diverse functions that are controlled by
surface receptors for antigen, costimulatory molecules, cytokines, chemokines, and other …

In recent years, substantial progress has been made towards the identification of
intracellular signalling molecules that couple multi-subunit immune-recognition receptors …

One remarkable feature of the immune system is its capacity to maintain constant numbers
of resting immune cells despite the complex nature of signals needed throughout …

Transcription factor GATA-1 is essential for erythroid and megakaryocytic maturation. GATA-
1 mutations are associated with hematopoietic precursor proliferation and leukemogenesis …

Abstract Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN)
phosphatase serve essential functions in the regulation of cell growth, differentiation and …

Cell cycle arrest by FoxO transcription factors involves transcriptional repression of cyclin D,
although the exact mechanism remains unclear. In this study, we used the BCR-ABL …

Mature B-lymphocytes develop sequentially from transitional type 1 (T1) and type 2 (T2)
precursors in the spleen. To elucidate the mechanisms that regulate the developmental fate …

Despite very similar gene expression profiles, the clinical course of B-cell chronic
lymphocytic leukemia (B-CLL) is heterogeneous. Immunoglobulin VH (IgVH) mutational …