NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative
pathogen of current COVID-19 pandemic, and insufficient production of type I interferon (IFN …

Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …

Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …

Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from
proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their …

Although known for many years as a nuclear factor (NF)-κB inhibitory and antiapoptotic
signaling protein, A20 has recently attracted much attention because of its ubiquitin …