NF-κB is an integral component of the immune response to Toxoplasma gondii. Although
evidence exists that T. gondii can directly modulate the NF-κB pathway, the parasite-derived …

Nrf2 is a transcription factor that has emerged as the cell's main defense mechanism against
many harmful environmental toxicants and carcinogens. Nrf2 is negatively regulated by …

The nuclear factor κB (NF-κB) transcription factor regulates cellular stress responses and the
immune response to infection. NF-κB activation results in oscillations in nuclear NF-κB …

Nuclear factor (NF)-κB has an important role in immunity and inappropriate NF-κB activity
has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms …

Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …

Ubiquitylation is a widely used post-translational protein modification that regulates many
biological processes, including immune responses. The role of ubiquitin in immune …

Several members of the NLR family of sensors activate innate immunity. In contrast, we
found here that NLRC3 inhibited Toll-like receptor (TLR)-dependent activation of the …

Our understanding of the molecular mechanisms that link inflammation and cancer has
significantly increased in recent years. Here, we analyse genetic evidence indicating that the …

Nuclear factor kappa enhancer binding protein (NF-κB) regulates diverse biological
processes including immunity, inflammation, and apoptosis. A vast array of cellular stimuli …

Protein ubiquitination is a reversible reaction, in which the ubiquitin chains are
deconjugated by a family of deubiquitinases (DUBs). The presence of a large number of …