Porcine epidemic diarrhea virus (PEDV) is the cause of an economically important swine
disease. Previous studies suggested that PEDV does not elicit a robust IFN response, but …

Ulcerative colitis (UC) and Crohn's disease (CD) are related polygenic inflammatory bowel
diseases (IBDs), with distinct and overlapping susceptibility loci. Recently, hypothesis-free …

Carbohydrate-specific signalling through DC-SIGN provides dendritic cells with plasticity to
tailor immunity to the nature of invading microbes. Here we demonstrate that recognition of …

The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional
corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as …

The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell‐bound and
secreted proteins that regulate numerous cellular processes. In particular, TNF‐family …

Objective: Our previous coeliac disease genome-wide association study (GWAS) implicated
risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To …

CD8+ T cells and natural killer (NK) cells are central cellular components of immune
responses against pathogens and cancer, which rely on interleukin (IL)-15 for homeostasis …

The RING domain protein RNF11 is overexpressed in breast cancers and promotes tumour
growth factor‐beta (TGF‐β) signalling. RNF11 has been proposed to regulate TGF‐β …

Ubiquitination, the covalent attachment of ubiquitin molecules to proteins, is emerging as a
widely utilized mechanism for rapidly regulating cell signaling. Recent studies indicate that …

Ubiquitin specific proteases (USPs) are the largest family of deubiquitinating enzymes
with∼ 56 members in humans. USPs regulate a wide variety of cellular processes by their …