As one of the most important post-translational modifications, ubiquitination plays versatile
roles in cancer-related pathways, and is involved in protein metabolism, cell-cycle …

The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in
inflammatory response following myocardial ischemia/reperfusion injury. Peli1, an E3 …

The tumor suppressor cylindromatosis (CYLD) inhibits the NFκB and mitogen-activated
protein kinase (MAPK) activation pathways by deubiquitinating upstream regulatory factors …

Cancer immunotherapy has become an attractive approach of cancer treatment with
tremendous success in treating various advanced malignancies. The development and …

After nuclear factor (NF)-κB activation, a complex network of negative feedback loops
ensures that the termination of the NF-κB response occurs in a highly organized manner …

Deubiquitylating enzymes (DUBs) remove ubiquitin chains from proteins and regulate
protein stability and function. USP7 is one of the most extensively studied DUBs, since USP7 …

Akt (also known as PKB) signaling orchestrates many aspects of biological functions and,
importantly, its deregulation is linked to cancer development. Akt activity is well-known …

Ubiquitylation is a crucial post-translational protein modification that regulates several
cellular processes in eukaryotes, including inflammatory responses, endocytic trafficking …

The innate immune response constitutes the first line of defense against viral infection and is
extensively regulated through ubiquitination. The removal of ubiquitin from innate immunity …

The proinflammatory cytokine interleukin-17 (IL-17) is the signature cytokine of the T helper
17 (TH17) subset of CD4+ T cells, and antibodies targeting IL-17 or the IL-17 receptor (IL …