[HTML][HTML] Streptococcus pneumoniae's virulence and host immunity: aging, diagnostics, and prevention

LRK Brooks, GI Mias - Frontiers in immunology, 2018 - frontiersin.org
Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

[HTML][HTML] Resistance mechanisms to antimicrobial peptides in gram-positive bacteria

L Assoni, B Milani, MR Carvalho… - Frontiers in …, 2020 - frontiersin.org
With the alarming increase of infections caused by pathogenic multidrug-resistant bacteria
over the last decades, antimicrobial peptides (AMPs) have been investigated as a potential …

High‐throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae

X Liu, C Gallay, M Kjos, A Domenech… - Molecular systems …, 2017 - embopress.org
Genome‐wide screens have discovered a large set of essential genes in the opportunistic
human pathogen Streptococcus pneumoniae. However, the functions of many essential …

[HTML][HTML] Sugar-coated killer: serotype 3 pneumococcal disease

JN Luck, H Tettelin, CJ Orihuela - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant
and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents …

Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci

T Azarian, PK Mitchell, M Georgieva… - PLoS …, 2018 - journals.plos.org
Streptococcus pneumoniae serotype 3 remains a significant cause of morbidity and mortality
worldwide, despite inclusion in the 13-valent pneumococcal conjugate vaccine (PCV13) …

Interim results of an ecological experiment—conjugate vaccination against the pneumococcus and serotype replacement

WP Hausdorff, WP Hanage - Human vaccines & …, 2016 - Taylor & Francis
Streptococcus pneumoniae has more than 95 serotypes, each of which presumably can
cause sepsis, meningitis, pneumonia, and acute otitis media. Pneumococcal conjugate …

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

JA Lees, B Ferwerda, PHC Kremer, NE Wheeler… - Nature …, 2019 - nature.com
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-
threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic …

Bacterial-host interactions: physiology and pathophysiology of respiratory infection

AP Hakansson, CJ Orihuela… - Physiological …, 2018 - journals.physiology.org
It has long been thought that respiratory infections are the direct result of acquisition of
pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some …

Influence of glycan structure on the colonization of Streptococcus pneumoniae on human respiratory epithelial cells

YY Chun, KS Tan, L Yu, M Pang… - Proceedings of the …, 2023 - National Acad Sciences
Virtually all living cells are encased in glycans. They perform key cellular functions such as
immunomodulation and cell–cell recognition. Yet, how their composition and configuration …

Improving vaccines against Streptococcus pneumoniae using synthetic glycans

P Kaplonek, N Khan, K Reppe… - Proceedings of the …, 2018 - National Acad Sciences
Streptococcus pneumoniae remains a deadly disease in small children and the elderly even
though conjugate and polysaccharide vaccines based on isolated capsular polysaccharides …