Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Simple Summary Despite the continuous development of treatment technology,
glioblastoma remains a challenge for modern medicine. The standard of care remains a …

Lung cancer is the leading cause of cancer-related death worldwide, and the survival rate of
metastatic lung cancer is exceedingly low. Helminthostatchys Zeylanica (H. Zeylanica) is a …

Simple Summary The most well-known oncogene and one with the highest rates of mutation
across all cancers is K-Ras, also known as the Kirsten rat sarcoma viral oncogene …

Colorectal cancer (CRC) is a heterogeneous disease with a myriad of alterations at the
cellular and molecular levels. Kristen rat sarcoma (KRAS) mutations occur in up to 40% of …

The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological
processes including proliferation, cell cycle control, growth, and survival; common across all …

Melittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-
helix structure. It has been reported that melittin can exert pharmacological effects, such as …

BRAF is one of the most frequently mutated oncogenes, with an overall frequency of about
50%. Targeting BRAF and its effector mitogen-activated protein kinase kinase 1/2 (MEK1/2) …

Purpose: Myeloproliferative neoplasms (MPN) are characterized by the overproduction of
differentiated myeloid cells. Mutations in JAK2, CALR, and MPL are considered drivers of …

The goal of the study was to produce, optimize, characterize, and compare crizotinib-loaded
lipid-polymer hybrid nanoparticles (CL-LPHNPs), representing a novel contribution to the …