Virulence and transmissibility of pathogens: what is the relationship?

M Lipsitch, ER Moxon - Trends in microbiology, 1997 - cell.com
The fitness of most pathogenic microorganisms depends on transmission from host to host.
This requires adaptation for dissemination, translocation and survival between hosts, as well …

Haemophilus influenzae type b conjugate vaccines

DF Kelly, ER Moxon, AJ Pollard - Immunology, 2004 - Wiley Online Library
Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial
infection in young children worldwide. During childhood, acquisition of antibody directed …

Reduction of nasopharyngeal carriage of pneumococci during the second year of life by a heptavalent conjugate pneumococcal vaccine

R Dagan, R Melamed, M Muallem… - Journal of Infectious …, 1996 - academic.oup.com
Children 12-18 months old were randomized to receive one dose of a conjugate heptavalent
pneumococcal vaccine, two doses of the same vaccine, or one dose of a 23-valent native …

Vaccination against colonizing bacteria with multiple serotypes

M Lipsitch - Proceedings of the National Academy of …, 1997 - National Acad Sciences
Conjugate vaccines protect vaccinated individuals against both disease from and
nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae …

Invasive Haemophilus influenzae infections after 3 decades of Hib protein conjugate vaccine use

MPE Slack, AW Cripps, K Grimwood… - Clinical microbiology …, 2021 - Am Soc Microbiol
Haemophilus influenzae serotype b (Hib) was previously the most common cause of
bacterial meningitis and an important etiologic agent of pneumonia in children aged< 5 …

The Impact Of Conjugate Vaccine On Carriage Of Haemophilus Influenzae Type B

ML Barbour, RT Mayon-White, C Coles… - Journal of Infectious …, 1995 - academic.oup.com
Conjugate vaccines against Haemophilus influenzae type b (Rib) may modify Rib
pharyngeal colonization. Rib colonization was compared in 371 infants and their families. In …

Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination

HJ Adam, SE Richardson, FB Jamieson, P Rawte… - Vaccine, 2010 - Elsevier
The epidemiology of invasive Haemophilus influenzae infections was evaluated in Ontario
between 1989 and 2007 to assess the impact of the introduction of the conjugate H …

The UK Hib vaccine experience

PT Heath, J McVernon - Archives of Disease in Childhood, 2002 - adc.bmj.com
Haemophilus influenzae type b (Hib) is an important pathogen in children< 5 years of age.
The Hib conjugate vaccines were the first polysaccharide–protein conjugate vaccines to be …

Conjugate vaccines and the carriage of Haemophilus influenzae type b.

ML Barbour - Emerging infectious diseases, 1996 - ncbi.nlm.nih.gov
Pharyngeal carriage of Haemophilus influenzae type b (Hib) is important in the transmission
of Hib organisms, the pathogenesis of Hib disease, and the development of immunity to the …

[HTML][HTML] Long Term Impact of Conjugate Vaccines on Haemophilus influenzae Meningitis: Narrative Review

MPE Slack - Microorganisms, 2021 - mdpi.com
H. influenzae serotype b (Hib) used to be the commonest cause of bacterial meningitis in
young children. The widespread use of Hib conjugate vaccine has profoundly altered the …