Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …

Proteoglycans (PGs) are a diverse family of proteins that consist of one or more
glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major …

Tissue engineering (TE) aims to mimic the complex environment where organogenesis
takes place using advanced materials to recapitulate the tissue niche. Cells, three …

The crucial roles of dermatan sulfate (DS) have been demonstrated in tissue development of
the cutis, blood vessels, and bone through construction of the extracellular matrix and cell …

Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently
attached to specific core proteins to form proteoglycans in their biosynthetic pathways. They …

There are five major classes of glycan including N-and O-glycans, glycosaminoglycans,
glycosphingolipids, and glycophosphatidylinositol anchors, all expressed at the molecular …

Musculocontractural Ehlers–Danlos Syndome (mcEDS) is a type of EDS caused by biallelic
pathogenic variants in the gene for carbohydrate sulfotransferase 14/dermatan 4-O …

Abstract Carbohydrate sulfotransferase 14/dermatan 4‐O‐sulfotransferase‐1
(CHST14/D4ST1) deficiency represents a specific form of Ehlers–Danlos syndrome (EDS) …

Proteoglycans consist of a core protein substituted with one or more glycosaminoglycan
(GAG) chains and execute versatile functions during many physiological and pathological …

During the resolution phase of normal skin wound healing, there is a considerable loss of
various cell types, including myofibroblasts by apoptosis. Inappropriate delay of apoptosis …