[HTML][HTML] Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
[HTML][HTML] Interleukins in cancer: from biology to therapy
Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?
The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …
therapeutic target in cancer therapy. It has been well established that transcription factor NF …
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
T Wang, C He - Cytokine & growth factor reviews, 2018 - Elsevier
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …
[HTML][HTML] Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments
L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …
inflammaging, is implicated in multiple disease states commonly observed in the elderly …
[HTML][HTML] Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer
Here, we utilized spontaneous models of pancreatic and lung cancer to examine how
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19
Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to
severe acute respiratory distress. The severity of the illness can also extend from mild …
severe acute respiratory distress. The severity of the illness can also extend from mild …
[HTML][HTML] Bacteroides fragilis toxin coordinates a pro-carcinogenic inflammatory cascade via targeting of colonic epithelial cells
Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part
via immune mechanisms that are incompletely understood. Using Apc Min mice colonized …
via immune mechanisms that are incompletely understood. Using Apc Min mice colonized …
Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg/Th17 cell imbalance in epithelial ovarian cancer
J Zhou, X Li, X Wu, T Zhang, Q Zhu, X Wang… - Cancer immunology …, 2018 - AACR
The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression
and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as …
and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as …
Cytokine‐and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …