[HTML][HTML] Sphingosine-1-phosphate metabolism in the regulation of obesity/type 2 diabetes
J Guitton, CL Bandet, ML Mariko, S Tan-Chen… - Cells, 2020 - mdpi.com
Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and
promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads …
promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads …
[HTML][HTML] Sphingolipid levels and signaling via resveratrol and antioxidant actions in cardiometabolic risk and disease
Resveratrol (RSV) is a phenolic compound with strong antioxidant activity, which is
generally associated with the beneficial effects of wine on human health. All resveratrol …
generally associated with the beneficial effects of wine on human health. All resveratrol …
[HTML][HTML] Gut microbiota in a mouse model of obesity and peripheral neuropathy associated with plasma and nerve lipidomics and nerve transcriptomics
Background Peripheral neuropathy (PN) is a common complication in obesity, prediabetes,
and type 2 diabetes, though its pathogenesis remains incompletely understood. In a murine …
and type 2 diabetes, though its pathogenesis remains incompletely understood. In a murine …
[HTML][HTML] Severity of COVID-19 patients predicted by serum sphingolipids signature
E Torretta, M Garziano, M Poliseno… - International Journal of …, 2021 - mdpi.com
The reason behind the high inter-individual variability in response to SARS-CoV-2 infection
and patient's outcome is poorly understood. The present study targets the sphingolipid …
and patient's outcome is poorly understood. The present study targets the sphingolipid …
[HTML][HTML] Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China
Background Animal studies suggest vital roles of sphingolipids, especially ceramides, in the
pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell …
pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell …
An integrated fecal microbiome and metabolomics in T2DM rats reveal antidiabetes effects from host‐microbial metabolic axis of EtOAc extract from Sophora …
J Shao, Y Liu, H Wang, Y Luo… - Oxidative Medicine and …, 2020 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease. Sophora flavescens (S.
flavescens), also named Kushen, is a famous Chinese herbal medicine that has been used …
flavescens), also named Kushen, is a famous Chinese herbal medicine that has been used …
Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes
F Afshinnia, EL Reynolds… - Annals of Clinical …, 2022 - Wiley Online Library
Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not
well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting …
well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting …
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes
Early and precise identification of individuals with prediabetes and type 2 diabetes (T2D) at
risk for progressing to chronic kidney disease (CKD) is essential to prevent complications of …
risk for progressing to chronic kidney disease (CKD) is essential to prevent complications of …
Plasma metabolomics and lipidomics differentiate obese individuals by peripheral neuropathy status
K Guo, MG Savelieff, AE Rumora… - The Journal of …, 2022 - academic.oup.com
Context Peripheral neuropathy (PN) is a frequent prediabetes and type 2 diabetes (T2D)
complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN …
complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN …
[HTML][HTML] Sex differences in cardiovascular diseases: a matter of estrogens, ceramides, and sphingosine 1-phosphate
The medical community recognizes sex-related differences in pathophysiology and
cardiovascular disease outcomes (CVD), culminating with heart failure. In general, pre …
cardiovascular disease outcomes (CVD), culminating with heart failure. In general, pre …