Natural products: A lead for drug discovery and development

B Chopra, AK Dhingra - Phytotherapy Research, 2021 - Wiley Online Library
Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

Kaempferol can reverse the 5-Fu resistance of colorectal cancer cells by inhibiting PKM2-mediated glycolysis

H Wu, J Du, C Li, H Li, H Guo, Z Li - International Journal of Molecular …, 2022 - mdpi.com
Resistance to 5-Fluorouracil (5-Fu) chemotherapy is the main cause of treatment failure in
the cure of colon cancer. Therefore, there is an urgent need to explore a safe and effective …

A review on terpenes for treatment of gastric cancer: current status and nanotechnology-enabled future

K Attri, D Sharda, B Chudasama, RL Mahajan… - RSC …, 2023 - pubs.rsc.org
Eighty-five percent of gastric cancer is caused by Helicobacter pylori infection. Delays in
detection, limited efficacy, and significant side effects of the available treatments lead to a 5 …

Discovery of triazolyl derivatives of cucurbitacin B targeting IGF2BP1 against non-small cell lung cancer

FF Shang, Q Lu, T Lin, M Pu, R Xiao… - Journal of Medicinal …, 2023 - ACS Publications
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product. Herein, we designed
and synthesized 2-OH-and 16-OH-modified CuB derivatives to improve their antitumor …

Tumor-associated macrophages: Potential target of natural compounds for management of breast cancer

RR Malla, V Padmaraju, DB Kundrapu - Life Sciences, 2022 - Elsevier
A large body of experimental research reveals that tumor-associated macrophages (TAMs)
are the major immunosuppressor cells in the breast tumor microenvironment (TME). The …

Exploring the potential of bioactive compounds in preventing cancer growth and progression: A comprehensive review

M Foroughi-Gilvaee, D Martirosyan… - Bioactive Compounds in …, 2024 - ffhdj.com
Cancer stands as a prominent global cause of mortality, with a noteworthy surge in related
deaths in recent years. Over the past decade, several bioactive compounds have emerged …

Phytochemical characterisation of dichloromethane and methanolic extracts of the Ziziphora tenuior leaves and evaluation of their antioxidant and antibacterial …

A Hatami - Natural Product Research, 2024 - Taylor & Francis
Medicinal plants, known for their antibacterial phytocompounds and secondary metabolites,
offer promising potential in combating antibiotic-resistant bacteria. This study aimed to …

Spectroscopic and spectrometric applications for the identification of bioactive compounds from vegetal Extracts

JD Lozada-Ramírez, AE Ortega-Regules… - Applied Sciences, 2021 - mdpi.com
Featured Application Separation and quantification by chromatographic methods, combined
with spectroscopic and spectrometric techniques, are relevant in the characterization and …

Myrcene exerts anti-tumor effects on oral cancer cells in vitro via induction of apoptosis

Z Wu, Z Li, Y Liang - Tropical Journal of Pharmaceutical Research, 2022 - ajol.info
Myrcene exerts anti-tumor effects on oral cancer cells in vitro via induction of apoptosis Page 1
Wu et al Trop J Pharm Res, May 2022; 21(5): 933 Tropical Journal of Pharmaceutical …

Bakuchiol: A potential anticancer compound from Psoralea corylifolia linn

B Chopra, AK Dhingra, AS Grewal… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Background: Bakuchiol is a monoterpene phenol isolated from the seeds of Psoralea
corylifolia Linn. It is used traditionally in Indian and Chinese medicine and has been …