Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors
VE van der Noord, W van der Stel, G Louwerens… - Breast Cancer …, 2023 - Springer
Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited
treatment options and poor clinical prognosis. Inhibitors of transcriptional CDKs are currently …
treatment options and poor clinical prognosis. Inhibitors of transcriptional CDKs are currently …
Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway
L Yang, F Zhou, Y Zhuang, Y Liu, L Xu, H Zhao… - British journal of …, 2021 - nature.com
Background Cyclin-dependent kinase 9 (CDK9) is a promising prognostic marker and
therapeutic target in cancers. Bufalin is an effective anti-tumour agent; however, the clinical …
therapeutic target in cancers. Bufalin is an effective anti-tumour agent; however, the clinical …
Recent trends and advances in novel formulations as an armament in Bcl-2/Bax targeted breast cancer
S Samia, PS Chary, O Khan, NK Mehra - International Journal of …, 2024 - Elsevier
Breast cancer (BC) remains a significant health burden worldwide, necessitating the
development of innovative therapeutic strategies. The B-cell lymphoma 2 (Bcl-2) family …
development of innovative therapeutic strategies. The B-cell lymphoma 2 (Bcl-2) family …
MCL-1 is a clinically targetable vulnerability in breast cancer
ML Winder, KJ Campbell - Cell Cycle, 2022 - Taylor & Francis
Pro-survival members of the BCL-2 family, including MCL-1, are emerging as important
proteins during the development and therapeutic response of solid tumors. Notably, high …
proteins during the development and therapeutic response of solid tumors. Notably, high …
CDK9 inhibitors in cancer research
Z Huang, T Wang, C Wang, Y Fan - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Cyclin dependent kinase 9 (CDK9) plays an essential role in regulating transcriptional
elongation. Aberrations in CDK9 activity have been observed in various cancers, which …
elongation. Aberrations in CDK9 activity have been observed in various cancers, which …
BH3-mimetics: recent developments in cancer therapy
PA Townsend, MV Kozhevnikova, ONF Cexus… - Journal of Experimental …, 2021 - Springer
The hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a
number of solid paradigms for targeting intermediates from the apoptosis pathway in a …
number of solid paradigms for targeting intermediates from the apoptosis pathway in a …
Cyclin-dependent kinase inhibitors in hematological malignancies—current understanding,(pre-) clinical application and promising approaches
A Richter, N Schoenwaelder, S Sender, C Junghanss… - Cancers, 2021 - mdpi.com
Simple Summary Cyclin-dependent kinases are involved in the regulation of cancer-
initiating processes like cell cycle progression, transcription, and DNA repair. In …
initiating processes like cell cycle progression, transcription, and DNA repair. In …
BH3 mimetics in AML therapy: death and beyond?
C Cerella, M Dicato, M Diederich - Trends in Pharmacological Sciences, 2020 - cell.com
B cell lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics are targeted therapeutic
agents that allow response prediction and patient stratification. BH3 mimetics are …
agents that allow response prediction and patient stratification. BH3 mimetics are …
Super enhancers as master gene regulators in the pathogenesis of hematologic malignancies
S Dębek, P Juszczyński - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Transcriptional deregulation of multiple oncogenes, tumor suppressors and survival
pathways is a cancer cell hallmark. Super enhancers (SE) are long stretches of active …
pathways is a cancer cell hallmark. Super enhancers (SE) are long stretches of active …
The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action
R Chen, J Tsai, PA Thompson, Y Chen, P Xiong… - Blood cancer …, 2021 - nature.com
The constitutive activation of B-cell receptor (BCR) signaling, together with the
overexpression of the Bcl-2 family anti-apoptotic proteins, represents two hallmarks of …
overexpression of the Bcl-2 family anti-apoptotic proteins, represents two hallmarks of …