Heterobifunctional polypharmacologic agents are compounds that have individual
pharmacophores for at least two separate biological targets. Our work spans two distinct sets …

Heterobifunctional polypharmacologic agents are compounds that have individual
pharmacophores for at least two separate biological targets. Our work spans two distinct sets …

In the past decade, inhibition of B-cell receptor-associated (BCR) Bruton tyrosine kinase
(BTK), phosphoinotiside-3 kinase (PI3K), and the pro-survival protein BCL2 using small …

Over the last 50 years, there has been a steady improvement in the treatment outcome of
acute myeloid leukemia (AML). However, median survival in the elderly is still poor due to …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer defined by
lack of the estrogen, progesterone and human epidermal growth factor receptor 2. Although …

2023-01-27 Assigned to PRELUDE THERAPEUTICS, INCORPORATED reassignment
PRELUDE THERAPEUTICS, INCORPORATED ASSIGNMENT OF ASSIGNORS INTEREST …

TVTXCJFHQKSQQM-LJQIRTBHSA-N 4-[[(2r, 3s, 4r, 5s)-3-(3-chloro-2-fluorophenyl)-4-(4-
chloro-2-fluorophenyl)-4-cyano-5-(2, 2-dimethylpropyl) pyrrolidine-2-carbonyl] amino]-3 …

Acute myeloid leukaemia (AML) is one of the most common haematological malignancies,
characterised by the clonal expansion of abnormal or poorly differentiated myeloid cells …

Exploring the Use of BH3-mimetics for the Treatment of Sarcomas Page 1 Exploring the Use of
BH3-mimetics for the Treatment of Sarcomas Submitted by Seirian Hart Bachelor of …

Cancer is amongst the leading causes of death in childhood. Rhabdomyosarcoma (RMS) is
the most frequently occurring soft tissue sarcoma in children and adolescents. It presumably …