An understanding of the molecular pathogenesis and heterogeneity of ovarian cancer holds
promise for the development of early detection strategies and novel, efficient therapies. In …

Background Dietary intake of lycopene has been associated with a reduced risk of ovarian
cancer, suggesting its chemopreventive potential against ovarian carcinogenesis …

Background We have previously shown that a whole flaxseed supplemented diet decreased
the onset and severity of ovarian cancer in the laying hen, the only known animal model of …

The domestic laying chicken has been intensely selected to be a persistent ovulator. That is,
the tendency for broodiness has been nearly eliminated and, given the appropriate lighting …

Health of the reproductive organs is essential for formation and production of high quality
and hygienic eggs. It is of importance to review the structures and functions of female …

Ovarian cancer (OC) is the leading cause of death from a gynecological malignancy in the
United States. By the time a woman is diagnosed with OC, the tumor has usually …

A quantitative mass spectrometry imaging (QMSI) method for absolute quantification of
glutathione (GSH) in healthy and cancerous hen ovarian tissues using infrared matrix …

Mass spectrometry imaging (MSI) is a rapidly evolving field for monitoring the spatial
distribution and abundance of analytes in biological tissue sections. It allows for direct and …

Chronic inflammation fundamentally influences cancer risk and development. A mechanism
of chronic inflammation is the formation of inflammasome complexes which results in the …

OBJECTIVE: With the exception of the laying hen, no other animal model of spontaneous
ovarian surface epithelial cancer replicates the human disease. Flaxseed is the richest …