The wingless-type MMTV integration site family of proteins (WNTs) is highly conserved
secreted lipid-modified signaling molecules that play a variety of pivotal roles in …

Objective: Because of the lack of an effective early detection test, ovarian cancer (OVCA) in
most cases is detected at late stages and remains a fatal gynecological malignancy …

Tumor-associated neoangiogenesis (TAN) is an early event in ovarian cancer (OVCA)
development. Increased expression of vascular endothelial growth factor receptor 2 …

Chronic inflammation has been linked to cancer. Prostaglandin E2 (PGE2) is the most pro-
inflammatory lipid and one of the downstream products of 2 isoforms of cyclooxygenase …

Preclinical models are relatively underutilized and underfunded resources for modeling the
pathogenesis and prevention of ovarian cancers. Several reviews have detailed the …

DNA methyltransferases (DNMTs) are key regulators of DNA methylation and have crucial
roles in carcinogenesis, embryogenesis and epigenetic modification. In general, DNMT1 …

Secreted phosphoprotein 1 (SPP1), a highly phosphorylated protein containing a
polyaspartic acid sequence and a conserved RGD motif, plays important roles in …

Objective Our goal was to examine the feasibility of using laying hens, a preclinical model of
human spontaneous ovarian cancer, in determining the kinetics of an ultrasound contrast …

As serine and cysteine proteinase inhibitors, serpins, such as SERPINB5, cause ovarian,
colorectal and pancreatic adenocarcinomas. We identified SERPINB11 as a novel estrogen …

Background The laying hen model of spontaneous epithelial ovarian cancer (EOC) is
unique in that it is the only model that enables observations of early events in disease …