Although the first discovery of a non-coding RNA (ncRNA) dates back to 1958, only in recent
years has the complexity of the transcriptome started to be elucidated. However, its …

Recently developed methods to predict three-dimensional protein structure with high
accuracy have opened new avenues for genome and proteome research. We explore a new …

Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have
apparent protein-coding roles, but they have been verified to play important roles in diverse …

Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are
the second most abundant type of RNA in the cell. Advancement in deep-sequencing …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Breast cancer (BC) is the most common malignancy among women worldwide. Like many
other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various …

Neurodegenerative diseases (NDs) are becoming increasingly prevalent in the world, with
an aging population. In the last few decades, due to the devastating nature of these …

Background: The discovery that much of the non–protein-coding genome is transcribed and
plays a diverse functional role in fundamental cellular processes has led to an explosion in …

Non-coding RNA (ncRNA) molecules have fundamental roles in cells and many are also
stable in body fluids as extracellular RNAs. In this study, we used RNA sequencing (RNA …

Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian
genome function; however, many of its physical features at the single-cell level remain …