Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian
genome function; however, many of its physical features at the single-cell level remain …

Hybrid RNA: DNA origami, in which a long RNA scaffold strand folds into a target
nanostructure via thermal annealing with complementary DNA oligos, has only been …

The human genome encodes thousands of long noncoding RNAs (lncRNAs), the majority of
which are poorly conserved and uncharacterized. Here we identify a primate-specific …

Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic
alterations. However, the mechanisms underlying oral squamous cell carcinoma …

The epithelial–mesenchymal transition (EMT) is thought to be at the root of invasive and
metastatic cancer cell spreading. E-cadherin is an important player in this process, which …

Life is confronted with computation problems in a variety of domains including animal
behavior, single-cell behavior, and embryonic development. Yet we currently do not know of …

Circular RNAs (circRNAs) are a class of non-coding RNA that were previously thought to be
insignificant byproducts of splicing errors. However, recent advances in RNA sequencing …

The recognition of RNA functions beyond canonical protein synthesis has challenged the
central dogma of molecular biology. Indeed, RNA is now known to directly regulate many …

Intricate layers of regulation determine the unique gene expression profiles of a given cell
and, therefore, underlie the immense phenotypic diversity observed among cell types …

Long noncoding RNAs (lncRNAs) are a group of noncoding cellular RNAs involved in
significant biological phenomena such as differentiation, cell development, genomic …