Role of noncoding RNAs in the pathogenesis of abdominal aortic aneurysm: possible therapeutic targets?

S Kumar, RA Boon, L Maegdefessel… - Circulation …, 2019 - Am Heart Assoc
Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall
and is among the most challenging cardiovascular diseases as without urgent surgical …

rDNA magnification is a unique feature of germline stem cells

JO Nelson, T Kumon… - Proceedings of the …, 2023 - National Acad Sciences
Ribosomal DNA (rDNA) encodes ribosomal RNA and exists as tandem repeats of hundreds
of copies in the eukaryotic genome to meet the high demand of ribosome biogenesis …

Extracellular vesicles in tissue engineering: biology and engineered strategy

Z Pan, W Sun, Y Chen, H Tang, W Lin… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs), acting as an important ingredient of intercellular communication
through paracrine actions, have gained tremendous attention in the field of tissue …

Sequence determinants for nuclear retention and cytoplasmic export of mRNAs and lncRNAs

AF Palazzo, ES Lee - Frontiers in genetics, 2018 - frontiersin.org
Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …

What are the distinguishing features and size requirements of biomolecular condensates and their implications for RNA-containing condensates?

JD Forman-Kay, JA Ditlev, ML Nosella, HO Lee - RNA, 2022 - rnajournal.cshlp.org
Exciting recent work has highlighted that numerous cellular compartments lack
encapsulating lipid bilayers (often called “membraneless organelles”), and that their …

CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA-and RBP-dependent manner

S Qiu, B Li, Y Xia, Z Xuan, Z Li, L Xie, C Gu, J Lv… - Cell death & …, 2022 - nature.com
Circular RNAs (circRNAs) play vital regulatory roles in the progression of multiple cancers.
In our study, transcriptome analysis and self-organizing maps (SOM) were applied to screen …

Gene-specific control of tRNA expression by RNA polymerase II

A Gerber, K Ito, CS Chu, RG Roeder - Molecular cell, 2020 - cell.com
Increasing evidence suggests that tRNA levels are dynamically and specifically regulated in
response to internal and external cues to modulate the cellular translational program …

Long non-coding RNAs: mechanisms, experimental, and computational approaches in identification, characterization, and their biomarker potential in cancer

A Chowdhary, V Satagopam, R Schneider - Frontiers in Genetics, 2021 - frontiersin.org
Long non-coding RNAs are diverse class of non-coding RNA molecules> 200 base pairs of
length having various functions like gene regulation, dosage compensation, epigenetic …

Long noncoding RNAs: a missing link in osteoporosis

AM Silva, SR Moura, JH Teixeira, MA Barbosa… - Bone research, 2019 - nature.com
Osteoporosis is a systemic disease that results in loss of bone density and increased
fracture risk, particularly in the vertebrae and the hip. This condition and associated …

Translational perspective on epigenetics in cardiovascular disease

P van der Harst, LJ de Windt, JC Chambers - Journal of the American …, 2017 - jacc.org
A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …