The increasing incidence of a variety of cancers after the Second World War confronts
scientists with the question of their origin. In Western countries, expansion and ageing of the …

Purpose Ovarian cancer (OC) patients experiencing progressive disease (PD) within 6
months of platinum-based therapy in the primary setting are considered platinum resistant …

Background: Risk prediction models for breast cancer can be improved by the addition of
recently identified risk factors, including breast density and use of hormone therapy. We …

Abstract BACKGROUND. The American Cancer Society, the Centers for Disease Control
and Prevention, the National Cancer Institute, and the North American Association of Central …

Context There is concern that mastectomy is overused in the United States. Objectives To
evaluate the association of patient-reported initial recommendations by surgeons and those …

Delivery of nanoparticle drugs to tumors relies heavily on the enhanced permeability and
retention (EPR) effect. While many consider the effect to be equally effective on all tumors, it …

We are in the midst of a technological revolution that is providing new insights into human
biology and cancer. In this era of big data, we are amassing large amounts of information …

Activation of Notch-1 is known to be associated with the development and progression of
human malignancies including pancreatic cancer. Emerging evidence suggest that the …

Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore,
it is of especial interest to set new strategies aimed at improving the prognostic of this deadly …

Objective Non-alcoholic fatty liver disease (NAFLD) affects 20–40% of the general adult
population. Due to shared risk factors, it is postulated that NAFLD patients have an …