Oxytocin, vasopressin, and social behavior: from neural circuits to clinical opportunities

N Rigney, GJ de Vries, A Petrulis, LJ Young - Endocrinology, 2022 - academic.oup.com
Oxytocin and vasopressin are peptide hormones secreted from the pituitary that are well
known for their peripheral endocrine effects on childbirth/nursing and blood pressure/urine …

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

A Annamneedi, C Gora, A Dudas… - British journal of …, 2023 - Wiley Online Library
Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two
core symptoms: deficits in social interaction and communication, and stereotyped …

[HTML][HTML] Modulation of social behavior by distinct vasopressin sources

N Rigney, GJ de Vries, A Petrulis - Frontiers in Endocrinology, 2023 - frontiersin.org
The neuropeptide arginine-vasopressin (AVP) is well known for its peripheral effects on
blood pressure and antidiuresis. However, AVP also modulates various social and anxiety …

[HTML][HTML] Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin

F Holze, I Avedisian, N Varghese, A Eckert… - Frontiers in …, 2021 - frontiersin.org
The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research,
including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual …

[HTML][HTML] Effects of intranasal administration of oxytocin and vasopressin on social cognition and potential routes and mechanisms of action

S Yao, KM Kendrick - Pharmaceutics, 2022 - mdpi.com
Acute and chronic administration of intranasal oxytocin and vasopressin have been
extensively utilized in both animal models and human preclinical and clinical studies over …

[HTML][HTML] Oxytocin and related peptide hormones: Candidate anti-inflammatory therapy in early stages of sepsis

SF Mehdi, S Pusapati, RR Khenhrani… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a potentially life-threatening systemic inflammatory syndrome characterized by
dysregulated host immunological responses to infection. Uncontrolled immune cell …

Linking oxytocin and arginine vasopressin signaling abnormalities to social behavior impairments in Prader-Willi syndrome

O Oztan, O Zyga, DEJ Stafford, KJ Parker - Neuroscience & Biobehavioral …, 2022 - Elsevier
Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder. Global
hypothalamic dysfunction is a core feature of PWS and has been implicated as a driver of …

Oxytocin administration enhances pleasantness and neural responses to gentle stroking but not moderate pressure social touch by increasing peripheral …

Y Chen, H Zou, X Hou, C Lan, J Wang, Y Qing, W Chen… - Elife, 2023 - elifesciences.org
Background: Social touch constitutes a key component of human social relationships,
although in some conditions with social dysfunction, such as autism, it can be perceived as …

Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits

L Clarke, O Zyga, PL Pineo-Cavanaugh, M Jeng… - Neuroscience & …, 2022 - Elsevier
Disorders involving hypothalamic and pituitary (HPIT) structures—including
craniopharyngioma, Langerhans cell histiocytosis, and intracranial germ cell tumors—can …

Photoswitchable Probes of Oxytocin and Vasopressin

U Wirth, K Raabe, P Kalaba, E Keimpema… - Journal of Medicinal …, 2023 - ACS Publications
Oxytocin (OT) and vasopressin (VP) are related neuropeptides that regulate many biological
processes. In humans, OT and VP act via four G protein-coupled receptors, OTR, V1aR …