Nanoparticles in drug delivery: From history to therapeutic applications

O Afzal, ASA Altamimi, MS Nadeem, SI Alzarea… - Nanomaterials, 2022 - mdpi.com
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs)
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …

Mesoporous silica nanoparticles as a versatile nanocarrier for cancer treatment: A review

AS Taleghani, AT Nakhjiri, MJ Khakzad… - Journal of Molecular …, 2021 - Elsevier
Curing cancer has drastically improved in recent decades, but it is essential to find more
effective and specific treatments. Radiotherapy and chemotherapy can cause serious side …

Non-viral carriers for nucleic acids delivery: Fundamentals and current applications

S Shtykalova, D Deviatkin, S Freund, A Egorova… - Life, 2023 - mdpi.com
Simple Summary Gene therapy is one of the most promising approaches to treating various
inherited and acquired diseases by delivering genetic constructs into the cells and tissues of …

Nanocarrier-based drug delivery system for cancer therapeutics: a review of the last decade

M Sohail, W Guo, Z Li, H Xu, F Zhao… - Current Medicinal …, 2021 - ingentaconnect.com
In recent years, due to the shortcomings of conventional chemotherapy, such as poor
bioavailability, low treatment index, and unclear side effects, the focus of cancer research …

Silica-based gene delivery systems: From design to therapeutic applications

AM Carvalho, RA Cordeiro, H Faneca - Pharmaceutics, 2020 - mdpi.com
Advances in gene therapy have been foreshadowing its potential for the treatment of a vast
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …

Overcoming the non-kinetic activity of EGFR1 using multi-functionalized mesoporous silica nanocarrier for in vitro delivery of siRNA

J Parnian, L Ma'mani, MR Bakhtiari, M Safavi - Scientific Reports, 2022 - nature.com
Triple-negative breast cancer (TNBC) does not respond to HER2-targeted and hormone-
based medicines. Epidermal growth factor receptor 1 (EGFR1) is commonly overexpressed …

Characterization of iRGD-ligand modified arginine-histidine-rich peptides for nucleic acid therapeutics delivery to αvβ3 integrin-expressing cancer cells

A Egorova, A Selutin, M Maretina, S Selkov, V Baranov… - Pharmaceuticals, 2020 - mdpi.com
Efficient and specific delivery of nucleic acid (NA) therapeutics to tumor cells is extremely
important for cancer gene therapy. Various therapeutic strategies include delivery of DNA …

Mesoporous silica nanoparticle-modified electrode arrays of cochlear implants for delivery of siRNA-TGFβ1 into the inner ear

A Chen, Y Chen, S Liu, D Ma, J Tang… - Colloids and Surfaces B …, 2022 - Elsevier
Cochlear implants (CI) are widely used in patients to restore hearing function. Uncontrolled
fibrosis in the cochleae induced by excess secretion of TGFβ1 seriously affects the …

Bortezomib-loaded mesoporous silica nanoparticles selectively alter metabolism and induce death in multiple myeloma cells

A Nigro, L Frattaruolo, M Fava, I De Napoli, M Greco… - Cancers, 2020 - mdpi.com
Simple Summary Multiple myeloma (MM) is the second most common hematological
malignancy and, despite the great advances made in its management, the development of …

Biodegradable polymers grafted onto multifunctional mesoporous silica nanoparticles for gene delivery

EPF Nhavene, GF Andrade, JAQA Faria, DA Gomes… - ChemEngineering, 2018 - mdpi.com
Biodegradable polymer possesses significant potential for applications in different fields,
since flexibility gives rise to materials with great physical and mechanical property diversity …