Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights

K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …

Anti-tumor immune potentiation targets-engineered nanobiotechnologies: design principles and applications

R Jiao, X Lin, Q Zhang, Y Zhang, W Qin, Q Yang… - Progress in Materials …, 2023 - Elsevier
Combined therapeutic strategies hold promises in augmenting antigen release to enhance
anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond …

Biomaterials for in situ cell therapy

C Wang, S Wang, DD Kang, Y Dong - BMEMat, 2023 - Wiley Online Library
Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic
disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo …

Deep penetration of nanolevel drugs and micrometer-level T cells promoted by nanomotors for cancer immunochemotherapy

H Chen, T Shi, Y Wang, Z Liu, F Liu… - Journal of the …, 2021 - ACS Publications
The ability of nanomotors to promote the deep penetration of themselves and the loaded
drugs in diseased tissues has been proposed and confirmed. However, whether such …

Dual affinity to RBCs and target cells (DART) enhances both organ-and cell type-targeting of intravascular nanocarriers

LT Ferguson, ED Hood, T Shuvaeva, VV Shuvaev… - ACS …, 2022 - ACS Publications
A long-standing goal of nanomedicine is to improve a drug's benefit by loading it into a
nanocarrier that homes solely to a specific target cell and organ. Unfortunately, nanocarriers …

Nano-drug delivery systems for T cell-based immunotherapy

R Li, Z Chen, J Li, Z Dai, Y Yu - Nano Today, 2022 - Elsevier
T cell-based immunotherapy, which tackles T cell dysfunction and exhaustion, offers broad
promising for treating cancer. Various T cell-based immunotherapies, such as immune …

Molecular dynamics insight of interaction between the functionalized-carbon nanotube and cancerous cell membrane in doxorubicin delivery

A Kordzadeh, M Zarif, S Amjad-Iranagh - Computer Methods and Programs …, 2023 - Elsevier
Background and objective: Doxorubicin (DOX) is a known anticancer drug which is widely
used in cancer therapy. Carbon nanotubes (CNTs) are among the most promising platforms …

Applications of CRISPR technology in cellular immunotherapy

X Zhou, PA Renauer, L Zhou, SY Fang… - Immunological …, 2023 - Wiley Online Library
CRISPR technology has transformed multiple fields, including cancer and immunology.
CRISPR‐based gene editing and screening empowers direct genomic manipulation of …

In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

FY Su, QH Zhao, SN Dahotre, L Gamboa… - Science …, 2022 - science.org
Simultaneous delivery of mRNA to multiple populations of antigen (Ag)–specific CD8+ T
cells is challenging given the diversity of peptide epitopes and polymorphism of class I major …

A focus on “bio” in bio–nanoscience: the impact of biological factors on nanomaterial interactions

C Cortez‐Jugo, E Czuba‐Wojnilowicz… - Advanced …, 2021 - Wiley Online Library
Bio–nanoscience research encompasses studies on the interactions of nanomaterials with
biological structures or what is commonly referred to as the biointerface. Fundamental …