IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main
clinical entities: Crohn's disease and ulcerative colitis. Although Crohn's disease and …

The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …

In the last 10 years, we have learned much about the pathogenesis, diagnosis, and
management of intestinal fibrosis in patients with inflammatory bowel diseases. Just a …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

This ECCO topical review of the European Crohn's and Colitis Organisation [ECCO] focused
on prediction, diagnosis, and management of fibrostenosing Crohn's disease [CD]. The …

Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the
course of the development of fibrosis, certain parts of the intestine become narrowed …

The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global
public health challenge. Intestinal fibrosis leading to stricture formation and bowel …

Background & Aims Fibrosis is a common complication of inflammatory bowel diseases
(IBDs). The pregnane X receptor (PXR)(encoded by NR1I2) suppresses intestinal …

Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by
transmural inflammation along the alimentary tract. Changes in the microbial composition …

Colorectal cancer (CRC) is a complex and widespread disease, currently ranked as the third
most frequent cancer worldwide. It is well known that the gut microbiota has an essential role …