Neuromodulation by the immune system: a focus on cytokines
Interactions between the immune system and the nervous system have been described
mostly in the context of diseases. More recent studies have begun to reveal how certain …
mostly in the context of diseases. More recent studies have begun to reveal how certain …
Maternal immune activation: Implications for neuropsychiatric disorders
ML Estes, AK McAllister - Science, 2016 - science.org
Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …
[HTML][HTML] Shaping neuronal fate: functional heterogeneity of direct microglia-neuron interactions
The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …
and neurological disorders is increasingly recognized. However, until recently, the nature of …
[HTML][HTML] Composition of gut microbiota in children with autism spectrum disorder: a systematic review and meta-analysis
L Iglesias-Vázquez, G Van Ginkel Riba, V Arija… - Nutrients, 2020 - mdpi.com
Background: Autism spectrum disorder (ASD) is a public health problem and has a
prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and …
prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and …
[HTML][HTML] The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
A survey of human brain transcriptome diversity at the single cell level
The human brain is a tissue of vast complexity in terms of the cell types it comprises.
Conventional approaches to classifying cell types in the human brain at single cell …
Conventional approaches to classifying cell types in the human brain at single cell …
Ageing, neurodegeneration and brain rejuvenation
T Wyss-Coray - Nature, 2016 - nature.com
Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
G Gunner, L Cheadle, KM Johnson, P Ayata… - Nature …, 2019 - nature.com
Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic
connectivity. The extracellular signals, particularly neuron-derived molecules, that drive …
connectivity. The extracellular signals, particularly neuron-derived molecules, that drive …
[HTML][HTML] The intersection of amyloid beta and tau at synapses in Alzheimer's disease
TL Spires-Jones, BT Hyman - Neuron, 2014 - cell.com
The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …
neurons and degeneration of synapses, causes the debilitating dementia associated with …
[HTML][HTML] Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?
The brain and the immune system are not fully formed at birth, but rather continue to mature
in response to the postnatal environment. The two-way interaction between the brain and …
in response to the postnatal environment. The two-way interaction between the brain and …