Interactions between the immune system and the nervous system have been described
mostly in the context of diseases. More recent studies have begun to reveal how certain …

Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …

The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …

Background: Autism spectrum disorder (ASD) is a public health problem and has a
prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and …

In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …

The human brain is a tissue of vast complexity in terms of the cell types it comprises.
Conventional approaches to classifying cell types in the human brain at single cell …

Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic
connectivity. The extracellular signals, particularly neuron-derived molecules, that drive …

The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …

The brain and the immune system are not fully formed at birth, but rather continue to mature
in response to the postnatal environment. The two-way interaction between the brain and …