Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Simple Summary Breast cancer is considered the second most occurring cancer after lung
cancer globally. The treatment for breast cancer includes surgery, radiation, chemotherapy …

The human solute carrier (SLC) superfamily of transporters is comprised of over 400
membrane-bound proteins, and plays essential roles in a multitude of physiological and …

Polysaccharides are closely related to immune regulation, however, the effects of
polysaccharides from different sources may be different. Therefore, the impact of a pectic …

The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters
family found in humans. These proteins actively transport endogenous and exogenous …

The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …

Simple Summary The effectiveness and safety of the anti-cancer agent doxorubicin
(anthracycline group medicine) depend on the metabolism and retention of the drug in the …

Individual cells and epithelia control the chemical exchange with the surrounding
environment by the fine-tuned expression, localization, and function of an array of …

OCTN is a small subfamily of membrane transport proteins that belongs to the larger SLC22
family. Two of the three members of the subfamily, namely, OCTN2 and OCTN1, are present …

Conventional chemotherapeutic agents for colorectal cancer (CRC) cause systemic side
effects and eventually become less efficacious owing to the development of drug resistance …