Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …

Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …

The motor symptoms of Parkinson's disease (PD) mainly arise from degeneration of
dopamine neurons within the substantia nigra. As no disease-modifying PD therapies are …

In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …

Store-operated calcium entry (SOCE) is the flow of calcium ions (Ca 2+) into cells in
response to the depletion of intracellular Ca 2+ stores that reside predominantly in the …

The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER
pathological changes seen in PD patients at postmortem. Human induced pluripotent stem …

Ca2+-influx through L-type Ca2+-channels (LTCCs) is associated with activity-related
stressful oscillations of Ca2+ levels within dopaminergic (DA) neurons in the substantia …

Calcium is an ubiquitous second messenger used by any living cell. The fine-tuning of
intracellular free calcium concentration ([Ca 2+] i) homeostasis and signalling pathways is …

Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …

Transient receptor potential (TRP) channels are transmembrane protein complexes that play
important roles in the physiology and pathophysiology of both the central nervous system …