Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

In this review we discuss mucus, the viscoelastic secretion from goblet or mucous producing
cells that lines the epithelial surfaces of all organs exposed to the external world. Mucus is a …

Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis.
However, their aberrant overexpression and glycosylation in various malignancies facilitate …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …

Accumulating evidence suggests long noncoding RNAs (lncRNAs) play an important role in
cancer progression. However, the function of lncRNA SNHG7 in colorectal cancer (CRC) …

In the section “Synthesis of O-GalNAc Glycan Core Structures,” the following text was edited
to read:“Cosmc is an ER protein that appears to bind specifically to T synthase and ensures …

Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of
dysregulated glycosyltransferases and glycosidases. In particular, an increase in the …

Mucus provides protective functions in the gastrointestinal tract and plays an important role
in the adhesion of microorganisms to host surfaces. Mucin glycoproteins polymerize, forming …

Background The MUC2 mucin organizes the two mucus layers in the colon. This mucin
carries a large number of O-glycans that are assumed to be attachment sites for the …