BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in
mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Mammalian mitochondrial DNA (mtDNA) is a small, maternally inherited genome that codes
for 13 essential proteins in the respiratory chain. Mature oocytes contain more than 150 000 …

Oocyte maturation is a long process during which oocytes acquire their intrinsic ability to
support the subsequent stages of development in a stepwise manner, ultimately reaching …

The ability of an oocyte to undergo successful cytoplasmic and nuclear maturation,
fertilization and embryo development is referred to as the oocyte's quality or developmental …

Mitochondria provide the primary source of ATP in the oocyte and early embryo and
mitochondrial dysfunction and deficit of mitochondria‐derived ATP has been linked to …

Assisted reproduction technology (ART) has become an attractive option for infertility
treatment and holds tremendous promise. However, at present, there is still room for …

Mitochondrial metabolic capacity and DNA replication have both been shown to affect
oocyte quality, but it is unclear which one is more critical. In this study, immature oocytes …

Background In human oocytes, as in other mammalian ova, there is a significant variation in
the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in …