The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms

Y Liang, X Dai, Y Cao, X Wang, J Lu, L Xie, K Liu, X Li - Biochimie, 2023 - Elsevier
The global epidemic of diabetes has brought heavy pressure on public health. New effective
anti-diabetes strategies are urgently needed. Trigonelline is the main component of …

[HTML][HTML] Regulatory mechanism of icariin in cardiovascular and neurological diseases

Y Wang, C Shang, Y Zhang, L Xin, L Jiao… - Biomedicine & …, 2023 - Elsevier
Cardiovascular diseases (CVDs) and neurological diseases are widespread diseases with
substantial rates of morbidity and mortality around the world. For the past few years, the …

Research progress on classical traditional Chinese medicine formula xiaoyaosan in the treatment of depression

J Chen, C Lei, X Li, Q Wu, C Liu, Q Ma… - Frontiers in …, 2022 - frontiersin.org
Depression is an emotional disorder that is problematic in psychiatry owing to its unclear
etiology and unknown pathogenesis. Traditional Chinese medicine formulations such as …

Anti-depressant-like effect of fermented Gastrodia elata Bl. by regulating monoamine levels and BDNF/NMDAR pathways in mice

M Gao, Y Wu, L Yang, F Chen, L Li, Q Li… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Gastrodia elata Blume (GE) is a Chinese
medicinal herb commonly used to treat central nervous system-related diseases, including …

Antidepressant effects of South African plants: an appraisal of ethnobotanical surveys, ethnopharmacological and phytochemical studies

MB Bonokwane, M Lekhooa, M Struwig… - Frontiers in …, 2022 - frontiersin.org
Globally, the search for safe and potent natural-based treatment for depression is receiving
renewed interest given the numerous side-effects associated with many existing drugs. In …

Insights into the explicit protective activity of herbals in management of neurodegenerative and cerebrovascular disorders

T Behl, R Makkar, A Sehgal, N Sharma, S Singh… - Molecules, 2022 - mdpi.com
The longstanding progressive neurodegenerative conditions of the central nervous system
arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an …

DFO treatment protects against depression-like behaviors and cognitive impairment in CUMS mice

W Zhang, M Yu, Q Zhang, Z Yang, T Zhang - Brain Research Bulletin, 2022 - Elsevier
Depression has several negative effects on emotion as well as learning and memory
abilities. Previous studies showed that depression could exacerbate inflammation, which in …

Exercise intervention and improvement of negative emotions in children: a meta-analysis

J Li, X Jiang, Z Huang, T Shao - BMC pediatrics, 2023 - Springer
Background Anxiety, depression, and stress are the most common mental health problems
in childhood. Exercise interventions in childhood help to promote mental health. Objective …

Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta‐Analysis

R Wan, R Song, Y Fan, L Li, J Zhang… - Evidence‐Based …, 2021 - Wiley Online Library
Objective. Chaihu Jia Longgu Muli decoction (CLMD) is widely used in the treatment of
poststroke depression (PSD) in China. Some evidences show that it has advantages, but …

The role and mechanism of hyperoside against depression-like behavior in mice via the NLRP1 inflammasome

A Song, Z Wu, W Zhao, W Shi, R Cheng, J Jiang, Z Ni… - Medicina, 2022 - mdpi.com
Background and Objectives: Hypericum perforatum (HP) is widely used for depressive
therapy. Nevertheless, the antidepressant effect and potential mechanism of hyperoside …