Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis

M Wang, J Feng, D Zhou, J Wang - European Journal of Medical Research, 2023 - Springer
Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …

Anti-inflammatory effects of nutritionally relevant concentrations of oleuropein and hydroxytyrosol on peripheral blood mononuclear cells: an age-related analysis

F Pojero, F Gervasi, SD Fiore, A Aiello… - International Journal of …, 2023 - mdpi.com
Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The
Mediterranean diet is a non-invasive intervention to improve the chronic low-grade …

The effect of PEGylated graphene oxide nanoparticles on the Th17-Polarization of activated T helpers

S Zamorina, V Timganova, M Bochkova, K Shardina… - Materials, 2023 - mdpi.com
We investigated the direct effect of PEGylated graphene oxide (P-GO) nanoparticles on the
differentiation, viability, and cytokine profile of activated T helper type 17 (Th17) in vitro. The …

COVID-19 and Diarylamidines: The Parasitic Connection

J Hulme - International Journal of Molecular Sciences, 2023 - mdpi.com
As emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
(Omicron) continue to outpace and negate combinatorial vaccines and monoclonal antibody …

Nanostructured Coatings Based on Graphene Oxide for the Management of Periprosthetic Infections

S Constantinescu, AG Niculescu, A Hudiță… - International Journal of …, 2024 - mdpi.com
To modulate the bioactivity and boost the therapeutic outcome of implantable metallic
devices, biodegradable coatings based on polylactide (PLA) and graphene oxide …

[HTML][HTML] A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic …

M Zeng, JK Hodges, A Pokala, M Khalafi, GY Sasaki… - Nutrition Research, 2024 - Elsevier
Anti-inflammatory activities of catechin-rich green tea extract (GTE) in obese rodents protect
against metabolic endotoxemia by decreasing intestinal permeability and absorption of gut …

[HTML][HTML] Honokiol hexafluoro confers reversal of neuropathological markers of HIV infection in a murine SCID model

Z Zhang, A Scanlan, R Koneru, CR Morrell, MD Reece… - …, 2024 - Elsevier
Cognitive impairment remains a persistent challenge in people living with HIV (PWLH)
despite antiretroviral therapy (ART) due to ART's inability to eliminate brain HIV. HIV …

Deoxynivalenol triggers the expression of IL-8-related signaling cascades and decreases protein biosynthesis in primary monocyte-derived cells

C Nossol, P Landgraf, M Oster, S Kahlert… - Mycotoxin …, 2024 - Springer
Humans and their immune system are confronted with mold-contaminated food and/or mold-
contaminated air in daily life and indoor activities. This results in metabolic stress and …

Response of elephant peripheral blood mononuclear cells when stimulated with elephant endotheliotropic herpesvirus glycoprotein B (EEHV-gB)

T Sittisak, T Guntawang, S Srivorakul… - Veterinary Immunology …, 2023 - Elsevier
Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is the most highly
fatal infectious disease among young Asian elephants. Despite the fact that antiviral therapy …

Virtual structure-based docking and molecular dynamics of FDA-approved drugs for the identification of potential IKKB inhibitors possessing dopaminergic activity in …

PC Gurram, S Satarker, A Nassar, J Mudgal… - Chemical Papers, 2023 - Springer
In Alzheimer's disease (AD), neuroinflammation is detrimental in causing
neurodegeneration. In the central nervous system, inhibitor of nuclear factor kappa B kinase …