Current trends of essential trace elements in patients with chronic liver diseases
T Himoto, T Masaki - Nutrients, 2020 - mdpi.com
Essential trace elements play crucial roles in the maintenance of health, since they are
involved in many metabolic pathways. A deficiency or an excess of some trace elements …
involved in many metabolic pathways. A deficiency or an excess of some trace elements …
A perspective on the prospective use of AI in protein structure prediction
R Versini, S Sritharan, B Aykac Fas… - Journal of Chemical …, 2023 - ACS Publications
AlphaFold2 (AF2) and RoseTTaFold (RF) have revolutionized structural biology, serving as
highly reliable and effective methods for predicting protein structures. This article explores …
highly reliable and effective methods for predicting protein structures. This article explores …
De novo modelling of HEV replication polyprotein: Five-domain breakdown and involvement of flexibility in functional regulation
S Fieulaine, T Tubiana, S Bressanelli - Virology, 2023 - Elsevier
Hepatitis E virus (HEV), a major cause of acute viral hepatitis, is a single-stranded, positive-
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …
Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication
The genomes of positive-sense RNA viruses encode polyproteins that are essential for
mediating viral replication. These viral polyproteins must undergo proteolysis (also termed …
mediating viral replication. These viral polyproteins must undergo proteolysis (also termed …
Processing and subcellular localization of the hepatitis E virus replicase: identification of candidate viral factories
K Metzger, C Bentaleb, K Hervouet… - Frontiers in …, 2022 - frontiersin.org
Hepatitis E virus (HEV) is the major cause of acute hepatitis worldwide. HEV is a positive-
sense RNA virus expressing three open reading frames (ORFs). ORF1 encodes the ORF1 …
sense RNA virus expressing three open reading frames (ORFs). ORF1 encodes the ORF1 …
Structural aspects of hepatitis E virus
F Cancela, O Noceti, J Arbiza, S Mirazo - Archives of Virology, 2022 - Springer
Hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Hepatitis E is an
enterically transmitted zoonotic disease that causes large waterborne epidemic outbreaks in …
enterically transmitted zoonotic disease that causes large waterborne epidemic outbreaks in …
Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication
Hepatitis E virus (HEV) is an RNA virus responsible for over 20 million infections annually.
HEV's open reading frame (ORF) 1 polyprotein is essential for genome replication, though it …
HEV's open reading frame (ORF) 1 polyprotein is essential for genome replication, though it …
Structure prediction and analysis of hepatitis E virus non-structural proteins from the replication and transcription machinery by AlphaFold2
Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in humans globally.
Considered for a long while a public health issue only in developing countries, the HEV …
Considered for a long while a public health issue only in developing countries, the HEV …
The protease domain in HEV pORF1 mediates the replicase's localization to multivesicular bodies and its exosomal release
M Glitscher, IM Spannaus, F Behr, RO Murra… - Cellular and Molecular …, 2024 - Elsevier
Background A peculiar feature of the hepatitis E virus (HEV) is its reliance on the exosomal
route for viral release. Genomic replication is mediated via the viral polyprotein pORF1, yet …
route for viral release. Genomic replication is mediated via the viral polyprotein pORF1, yet …
[PDF][PDF] Hepatitis E virus RNA‐dependent RNA polymerase is involved in RNA replication and infectious particle production
N Oechslin, N Da Silva, D Szkolnicka… - …, 2022 - Wiley Online Library
Abstract Background and Aims Hepatitis E virus (HEV) is one of the most common causes of
acute hepatitis worldwide. Its positive‐strand RNA genome encodes three open reading …
acute hepatitis worldwide. Its positive‐strand RNA genome encodes three open reading …