[HTML][HTML] Senescent immune cells release grancalcin to promote skeletal aging
CJ Li, Y Xiao, YC Sun, WZ He, L Liu, M Huang, C He… - Cell metabolism, 2021 - cell.com
Skeletal aging is characterized by low bone turnover and marrow fat accumulation.
However, the underlying mechanism for this imbalance is unclear. Here, we show that …
However, the underlying mechanism for this imbalance is unclear. Here, we show that …
Single-cell RNA sequencing maps endothelial metabolic plasticity in pathological angiogenesis
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
[HTML][HTML] A quantitative tissue-specific landscape of protein redox regulation during aging
Mammalian tissues engage in specialized physiology that is regulated through reversible
modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a …
modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a …
Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS
Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC–MS/MS) is the
mainstay in proteome research because of its excellent sensitivity but often comes at the …
mainstay in proteome research because of its excellent sensitivity but often comes at the …
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication
Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
MatrisomeDB: the ECM-protein knowledge database
The extracellular matrix (ECM) is a complex and dynamic meshwork of cross-linked proteins
that supports cell polarization and functions and tissue organization and homeostasis. Over …
that supports cell polarization and functions and tissue organization and homeostasis. Over …
NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron–sulfur cluster proteins
Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in
homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound …
homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound …
[HTML][HTML] Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast
growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer. However …
growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer. However …
A high-stringency blueprint of the human proteome
Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …
(HPP) in 2010, creating an international framework for global collaboration, data sharing …