The bacterial superantigen and superantigen‐like proteins

JD Fraser, T Proft - Immunological reviews, 2008 - Wiley Online Library
The bacterial superantigens are protein toxins that bind to major histocompatibility complex
class II and T‐cell receptor to stimulate large numbers of T cells. The majority are produced …

Bacterial superantigens

T Proft, JD Fraser - Clinical & Experimental Immunology, 2003 - academic.oup.com
Superantigens (SAgs) are the most powerful T cell mitogens ever discovered.
Concentrations of less than 0· 1 pg/ml of a bacterial superantigen are sufficient to stimulate …

The pathogenic equine streptococci

J Timoney - Veterinary research, 2004 - hal.science
Streptococci pathogenic for the horse include S. equi (S. equi subsp. equi), S.
zooepidemicus (S. equi subsp. zooepidemicus), S. dysgalactiae subsp. equisimilis and S …

Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens

MTG Holden, Z Heather, R Paillot, KF Steward… - PLoS …, 2009 - journals.plos.org
The continued evolution of bacterial pathogens has major implications for both human and
animal disease, but the exchange of genetic material between host-restricted pathogens is …

The fundamental contribution of phages to GAS evolution, genome diversification and strain emergence

DJ Banks, SB Beres, JM Musser - Trends in microbiology, 2002 - cell.com
The human bacterial pathogen group A Streptococcus (GAS) causes many different
diseases including pharyngitis, tonsillitis, impetigo, scarlet fever, streptococcal toxic shock …

Staphylococcal and streptococcal superantigens: molecular, biological and clinical aspects

JE Alouf, H Müller-Alouf - International journal of medical microbiology, 2003 - Elsevier
Superantigens (SAgs) include a class of certain bacterial and viral proteins exhibiting highly
potent lymphocyte-transforming (mitogenic) activity towards human and or other mammalian …

Streptococcal superantigens: categorization and clinical associations

RJ Commons, PR Smeesters, T Proft, JD Fraser… - Trends in molecular …, 2014 - cell.com
Superantigens are key virulence factors in the immunopathogenesis of invasive disease
caused by group A streptococcus. These protein exotoxins have also been associated with …

Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

SB Beres, R Sesso, SWL Pinto, NP Hoe, SF Porcella… - PloS one, 2008 - journals.plos.org
Outbreaks of disease attributable to human error or natural causes can provide unique
opportunities to gain new information about host-pathogen interactions and new leads for …

New perspectives for the diagnosis, control, treatment, and prevention of strangles in horses

AS Waller - Veterinary Clinics: Equine Practice, 2014 - vetequine.theclinics.com
Strangles was first reported in 1251 by Jordanus Ruffus, 1 an officer in the imperial court of
Emperor Frederick II, although the disease almost certainly has older origins. Despite …

[HTML][HTML] Streptococcal superantigens: biological properties and potential role in disease

T Proft, JD Fraser - 2016 - europepmc.org
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …