The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Diabetic nephropathy (DN) is the leading cause of end‑stage renal disease. Although
Ginkgo biloba extract has a protective effect on DN, the protective effect and mechanism of …

Cellular senescence is frequently evident at etiologic sites of chronic diseases and involves
essentially irreversible arrest of cell proliferation, increased protein production, resistance to …

Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …

Circular RNA (circRNA) is a newly described type of non‐coding RNA. Active research is
greatly enriching the current understanding of the expression and role of circRNA, and a …

Diabetic kidney disease (DKD) is one of the most common complications of diabetes and is
clinically featured by progressive albuminuria, consequent to glomerular destruction that …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …

Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly
reduces lifespan, and its overexpression extends it and protects against various pathological …

The global epidemic of diabetes has brought heavy pressure on public health. New effective
anti-diabetes strategies are urgently needed. Trigonelline is the main component of …