Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: impact of drug-drug interactions and cigarette …
Tizanidine is an alpha2-adrenergic agonist, used to treat spasticity associated with multiple
sclerosis and spinal injury. Tizanidine is primarily metabolized by CYP1A2 and is …
sclerosis and spinal injury. Tizanidine is primarily metabolized by CYP1A2 and is …