Targeting ferroptosis as a vulnerability in cancer

G Lei, L Zhuang, B Gan - Nature Reviews Cancer, 2022 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

[PDF][PDF] Redox metabolism: ROS as specific molecular regulators of cell signaling and function

C Lennicke, HM Cochemé - Molecular Cell, 2021 - cell.com
Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Y Xiong, C Xiao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

[HTML][HTML] Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease

V Ngo, ML Duennwald - Antioxidants, 2022 - mdpi.com
Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Y Liu, Y Wan, Y Jiang, L Zhang, W Cheng - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Metal–organic frameworks (MOFs) as apt luminescent probes for the detection of biochemical analytes

D Luo, J Huang, Y Jian, A Singh, A Kumar… - Journal of Materials …, 2023 - pubs.rsc.org
The detection of active substances in the body is very important for good human health as it
gives important insights into the smooth functioning of the body. Most of the conventional …

Carbon quantum dots-based nanozyme from coffee induces cancer cell ferroptosis to activate antitumor immunity

L Yao, MM Zhao, QW Luo, YC Zhang, TT Liu, Z Yang… - ACS …, 2022 - ACS Publications
Carbon quantum dots (CQDs) offer huge potential due to their enzymatic properties as
compared to natural enzymes. Thus, discovery of CQDs-based nanozymes with low toxicity …

[HTML][HTML] Role of oxidative stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) infection: a review

S Suhail, J Zajac, C Fossum, H Lowater… - The protein journal, 2020 - Springer
Abstract Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic
and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several …

[HTML][HTML] Glutathione in the Brain

K Aoyama - International journal of molecular sciences, 2021 - mdpi.com
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the
antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH …

Copper-based metal–organic framework overcomes cancer chemoresistance through systemically disrupting dynamically balanced cellular redox homeostasis

J Liu, Y Yuan, Y Cheng, D Fu, Z Chen… - Journal of the …, 2022 - ACS Publications
Chemodrug resistance is a major reason accounting for tumor recurrence. Given the
mechanistic complexity of chemodrug resistance, molecular inhibitors and targeting drugs …