Chronic pain relief remains an unmet medical need. Current research points to a substantial
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …

Engineered neurobiological tools for the manipulation of cellular activity, such as
chemogenetics and optogenetics, have become a cornerstone of modern neuroscience …

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have proven
themselves as one of the key in vivo techniques of modern neuroscience, allowing for …

Conspectus Integrating functional materials and devices with living systems enables novel
methods for recording, manipulating, or augmenting organisms not accessible by traditional …

Atherosclerosis is the leading cause of mortality worldwide. However, regrettably, there are
no treatment options that target the root causes of the disease, as its pathogenic …

One important facet of glaucoma pathophysiology is axonal damage, which ultimately
disrupts the connection between the retina and its postsynaptic brain targets. The concurrent …

Controlling intracranial pressure, nerve cell regeneration, and microenvironment regulation
are the key issues in reducing mortality and disability in acute brain injury. There is currently …

The cardiovascular system is hardwired to the brain via multilayered afferent and efferent
polysynaptic axonal connections. Two major anatomically and functionally distinct though …

Anxiety disorders are among the most prevalent psychiatric disorders, with symptoms often
beginning early in life. To model the pathophysiology of human pathological anxiety, we …

Designer receptors exclusively activated by designer drugs (DREADDs) are a promising tool
for analyzing neural circuitry, and improved DREADD-selective ligands continue to be …