PA28 (also known as 11S, REG or PSME) is a family of proteasome regulators whose
members are widely present in many of the eukaryotic supergroups. In jawed vertebrates …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …

Aging is a primary risk factor for neurodegenerative disorders that involve protein
aggregation. Because lowering body temperature is one of the most effective mechanisms to …

The proteasome, a complex multi-catalytic protease machinery, orchestrates the protein
degradation essential for maintaining cellular homeostasis, and its dysregulation also …

The PA28 family proteasome activators play important roles in regulating proteasome
activities. Though the three paralogs (PA28α, PA28β, and PA28γ) are similar in terms of …

Proteasome activator 28γ (PA28γ/REGγ) is a member of the 11S family of proteasomal
regulators that is constitutively expressed in the nucleus and implicated in various diseases …

Cellular senescence is closely related to DNA damage, proteasome inactivity, histone loss,
epigenetic alterations, and tumorigenesis. The mammalian proteasome activator PA200 …

ABSTRACT PA28γ is a proteasomal interactor whose main and most known function is to
stimulate the hydrolytic activity of the 20S proteasome independently of ubiquitin and ATP …

Background Lung adenocarcinoma (LUAD) is one of the most common types of cancer
worldwide. Proteasome activator subunit 3 (PSME3) is a subunit of a proteasome activator …

A growing body of evidence convincingly indicates that proteasomes are not located
exclusively within cells but also in different extracellular compartments. In humans, in fact …