[HTML][HTML] Methods and applications of in silico aptamer design and modeling

AA Buglak, AV Samokhvalov, AV Zherdev… - International journal of …, 2020 - mdpi.com
Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …

Aptamer-functionalized liposomes for targeted cancer therapy

SA Moosavian, P Kesharwani, V Singh… - … Nanocarriers for Cancer …, 2023 - Elsevier
Liposomes are among the most well-documented drug delivery systems in anticancer
therapy owing to their passive targeting capacities besides inherent biocompatibility and …

[HTML][HTML] Identification and structural analysis of novel malathion-specific DNA aptameric sensors designed for food testing

US Kadam, KH Trinh, V Kumar, KW Lee, Y Cho… - Biomaterials, 2022 - Elsevier
Malathion is an organophosphate chemical (OPC) and a toxic contaminant that adversely
impacts food quality, human health, biodiversity, and the environment. Due to its small size …

[HTML][HTML] Design and prediction of aptamers assisted by in silico methods

SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …

[HTML][HTML] Capture-SELEX: selection strategy, aptamer identification, and biosensing application

SY Lam, HL Lau, CK Kwok - Biosensors, 2022 - mdpi.com
Small-molecule contaminants, such as antibiotics, pesticides, and plasticizers, have
emerged as one of the substances most detrimental to human health and the environment …

In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers

DR Bell, JK Weber, W Yin, T Huynh… - Proceedings of the …, 2020 - National Acad Sciences
Nucleic acid aptamers hold great promise for therapeutic applications due to their favorable
intrinsic properties, as well as high-throughput experimental selection techniques. Despite …

[HTML][HTML] Smart approach for the design of highly selective aptamer-based biosensors

A Douaki, D Garoli, AKMS Inam, MAC Angeli… - Biosensors, 2022 - mdpi.com
Aptamers are chemically synthesized single-stranded DNA or RNA oligonucleotides widely
used nowadays in sensors and nanoscale devices as highly sensitive biorecognition …

Docking-aided rational tailoring of a fluorescence-and affinity-enhancing aptamer for a label-free ratiometric malachite green point-of-care aptasensor

K Chen, L Zhu, Z Du, X Lan, K Huang, W Zhang… - Journal of Hazardous …, 2023 - Elsevier
Although nucleic acid aptasensors are increasingly applied in the detection of
environmentally hazardous biomolecules, several formidable challenges remain with this …

Fluorescent biosensor based on FRET and catalytic hairpin assembly for sensitive detection of polysialic acid by using a new screened DNA aptamer

J Chen, J Liu, J Wang, Y Zhang, X Wang, N Zhou - Talanta, 2022 - Elsevier
A fast and efficient dsDNA library-immobilized magnetic bead-based SELEX technique was
employed for selection of the aptamers against polysialic acid (PSA). Overall twelve rounds …

Identification and characterization of novel RdRp and Nsp15 inhibitors for SARS-COV2 using computational approach

S Barage, A Karthic, R Bavi, N Desai… - Journal of …, 2022 - Taylor & Francis
Abstract The World Health Organization has declared COVID-19 as a global health
emergency. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 …