Abstract Context.—“Undifferentiated tumor” refers to a heterogeneous group of neoplasms
with little or no evidence of differentiation on routine light microscopic morphology …

Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each
year more successful therapies are implemented. However, in a subset of cases the overall …

Most consensus leukemia & lymphoma antibody panels consist of lists of markers based on
expert opinions, but they have not been validated. Here we present the validated EuroFlow …

We analyzed the incidence, presenting features, risk factors of extramedullary (EM) relapse
occurring in acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) …

Abstract Purpose of Review Recent treatment advances in both acute myeloid leukemia and
acute lymphoblastic leukemia have drastically improved outcomes for these diseases, but …

Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease generally associated
with poor prognosis. Gene expression profiles indicate the existence of distinct molecular …

NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36),
exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute …

Extramedullary manifestations of acute myeloid leukemia (AML) were described as early as
the 19th century. However, the incidence, clinical significance and pathobiology of …

Neoplastic meningitis (NM) is a common problem in neuro-oncology occurring in
approximately 5% of all patients with cancer. Notwithstanding frequent focal signs and …

BACKGROUND: The expression of CD56 is considered a bad prognostic factor for overall
survival, lower rates or short complete remission and extramedullary invasion but the results …