During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …

Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …

Asthma is a chronic disease most commonly associated with allergy and type 2
inflammation. However, the mechanisms that link airway inflammation to the structural …

Background Human airway epithelial (HAE) cellular models are widely used in applicative
studies of the airway physiology and disease. In vitro expanded and differentiated primary …

In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can
end up in respiratory failure. Even though the main fibrotic disease affecting the lung is …

Cystic fibrosis (CF) is a life-threatening autosomal-recessive disease caused by mutations in
a single gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). CF …

The lung epithelium has long been overlooked as a key player in tuberculosis disease. In
addition to acting as a direct barrier to Mycobacterium tuberculosis (Mtb), epithelial cells …

The lungs are affected by illnesses including asthma, chronic obstructive pulmonary
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …

Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct
respiratory diseases that share features such as the obstruction of small airways and …

An overview of the application of natural and synthetic, non-viral vectors for oligonucleotide
delivery into the lung is presented in this review, with a special focus on lung cancer. Due to …