Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Pressure-dependent chronotropy of murine lymphatic collecting vessels relies on the
activation of the Ca 2+-activated chloride channel encoded by Anoctamin 1 (Ano1) in …

Key points We constructed a comprehensive mathematical model of the spontaneous
electrical activity of a human sinoatrial node (SAN) pacemaker cell, starting from the recent …

Background: The time variation between consecutive heartbeats is commonly referred to as
heart rate variability (HRV). Loss of complexity in HRV has been documented in several …

In this study, we report static and perfused models of human myocardial-microvascular
interaction. In static culture, we observe distinct regulation of electrophysiology of human …

Cardiac automaticity is set by pacemaker activity of the sinus node (SAN). In addition to the
ubiquitously expressed cardiac voltage-gated L-type Cav1. 2 Ca2+ channel isoform …

Background: Sinoatrial node cells (SANC) automaticity is generated by functional
association between the activity of plasmalemmal ion channels and local diastolic …

Lymphatic system defects are involved in a wide range of diseases, including obesity,
cardiovascular disease, and neurological disorders, such as Alzheimer's disease. Fluid …

Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and
contractile force. In the present study, we uncover the primary mechanism underlying the …