Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

Bone-forming cells originate from distinct embryological layers, mesoderm (axial and
appendicular bones) and ectoderm (precursor of neural crest cells, which mainly form facial …

Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome
achondroplasia. Using a limb culture system, we have analyzed the role of FGF signaling …

The best established proteolytic event of osteoclasts is bone matrix solubilization by the
cysteine proteinase cathepsin K. Here, however, we draw the attention on osteoclastic …

SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage
development and numerous other developmental events. In the foetal growth plate, Sox9 is …

The regeneration of adult skeletal tissues requires the timely recruitment of skeletal
progenitor cells to an injury site, the differentiation of these cells into bone or cartilage, and …

Histological and molecular analysis of fracture healing in normal and diabetic animals
showed significantly enhanced removal of cartilage in diabetic animals. Increased cartilage …

Abstract Exostosin1 (Ext1) belongs to a family of glycosyltransferases necessary for the
synthesis of the heparan sulfate (HS) chains of proteoglycans, which regulate signaling of …

Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …

The aim of this study was to examine the chronological histology associated with highly
purified β-tricalcium phosphate (β-TCP) implanted in the rat femoral condyle. Specimens …