[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

The microbiota-gut-brain axis in health and disease and its implications for translational research

MA Schächtle, SP Rosshart - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Over the past decades, microbiome research has evolved rapidly and became a hot topic in
basic, preclinical and clinical research, for the pharmaceutical industry and for the general …

Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice

Y Jiang, K Li, X Li, L Xu, Z Yang - Chemico-biological interactions, 2021 - Elsevier
Current strategies for the treatment of Alzheimer's disease (AD) focus on the pathology in the
later stages of disease progression. Early microglia abnormality and β-amyloid (Aβ) …

Gene regulation by histone-modifying enzymes under hypoxic conditions: a focus on histone methylation and acetylation

J Kim, H Lee, SJ Yi, K Kim - Experimental & Molecular Medicine, 2022 - nature.com
Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

A microbial-based approach to mental health: the potential of probiotics in the treatment of depression

D Johnson, V Letchumanan, CC Thum… - Nutrients, 2023 - mdpi.com
Probiotics are currently the subject of intensive research pursuits and also represent a multi-
billion-dollar global industry given their vast potential to improve human health. In addition …

New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics

G Dothel, MR Barbaro, A Di Vito, G Ravegnini… - Journal of …, 2023 - Springer
Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of
the gut–brain axis, intestinal permeability, mucosal neuro-immune interactions, and …

Short-chain fatty acids in the microbiota–gut–brain axis: role in neurodegenerative disorders and viral infections

A Majumdar, IP Siva Venkatesh… - ACS Chemical …, 2023 - ACS Publications
The gut–brain axis (GBA) is the umbrella term to include all bidirectional communication
between the brain and gastrointestinal (GI) tract in the mammalian body. Evidence from over …

Cellular immune signal exchange from ischemic stroke to intestinal lesions through brain-gut axis

Z Yang, F Wei, B Zhang, Y Luo, X Xing… - Frontiers in …, 2022 - frontiersin.org
As a vital pivot for the human circulatory system, the brain-gut axis is now being considered
as an important channel for many of the small immune molecules' transductions, including …

White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia

R Shao, D Sun, Y Hu, D Cui - Journal of Neuroscience …, 2021 - Wiley Online Library
Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white
matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy …

Probiotics, live biotherapeutic products (LBPs), and gut-brain axis related psychological conditions: implications for research and dietetics

D Ağagündüz, E Çelik, Ö Cemali, FG Bingöl… - Probiotics and …, 2023 - Springer
It is well-known that probiotics have key roles in the crosstalk between the gut and brain in
terms of nutrition and health. However, when investigating their role in nutrition and health, it …