Randomized controlled trials (RCTs) are conducted under idealized and rigorously
controlled conditions that may compromise their external validity. A literature review was …

The Head and Neck Squamous Cell Cancer (HNSCC) is the most common type of head and
neck cancer (more than 90%), and all over the world more than a half million people have …

Objectives The aim of this article was to provide practical guidance in setting up patient
registries to facilitate real-world data collection for health care decision making. Methods …

Decision makers increasingly request evidence on the real-world cost effectiveness of a new
treatment. There is, however, a lack of practical guidance on how to conduct an economic …

Background Representativeness in clinical trials (CT) serves as a metric of access to
healthcare and reflects differences that may determine differential efficacy of medical …

Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. Up to
20% of oral dysplasia cases have been suggested to undergo malignant transformation to …

Clinical trial EMR 62202-006 demonstrates prolonged median locoregional control (24.4 vs.
14.9 months), progression-free survival (17.1 vs. 12.4 months) and overall survival (49.0 vs …

Objectives Generalizability of trial-based cost-effectiveness estimates to real-world target
populations is important for decision making. In the context of independent aggregate time …

The growing pressure on healthcare budgets creates great tension between financial
sustainability of healthcare systems and accessibility to (new) treat¬ ments. To ensure equal …

Op 23 oktober 2015 promoveerde N. van der Linden aan de Erasmus Universiteit op het
proefschrift getiteld 'The use of realworld data in lung and head and neck oncology'. Het …