Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Single-cell sequencing (SCS) is an emerging high-throughput technology that can be used
to study the genomics, transcriptomics, and epigenetics at a single cell level. SCS is widely …

Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …

Liver cancer accounts for 6% of all malignancies causing death worldwide, and
hepatocellular carcinoma (HCC) is the most common histological type. HCC is a …

Simple Summary Defects in a DNA repair pathway called mismatch repair (MMR) can lead
to cancer, including colorectal cancer (CRC). The detection of mismatch repair deficiency …

Osteopontin (OPN) is a multifunctional phosphorylated protein. It is widely involved in solid
tumor progression, such as intensification of macrophage recruitment, inhibition of T-cell …

Triple-negative breast cancer (TNBC) is a broad collection of breast cancer that tests
negative for estrogen receptors (ER), progesterone receptors (PR), and excess human …

Heterogeneity describes the differences among the cancer cells within and between tumors.
It refers to cancer cells describing variations in morphology, transcriptional profiles …

Objectives: Triple-negative breast cancer (TNBC) is defined as a highly aggressive type of
breast cancer which lacks specific biomarkers and drug targets. Damage-associated …

Breast cancer development and progression rely not only on the proliferation of neoplastic
cells but also on the significant heterogeneity in the surrounding tumor microenvironment. Its …