Background: The invention and development of single-cell technologies have contributed a
lot to the understanding of tumor heterogeneity. The objective of this research was to …

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a
crucial role in antitumor immunity. However, the role of MIF in influencing the tumor …

Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease
that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and …

乳腺癌是全球女性发病率最高的恶性肿瘤, 也是女性癌症相关致死的主要原因之一.
乳腺癌是一种高度异质性的疾病, 肿瘤间异质性和肿瘤内异质性使得精准分型治疗工作进展缓慢 …

Objectives Bone marrow mesenchymal stem cells (BMSCs) are instrumental in bone
development, metabolism, and marrow microenvironment homeostasis. Despite this, the …

Clinical trials that have a pharmacokinetic or a pharmacodynamic immunologic mechanism
of action–based primary outcome could substantially improve the validity and efficiency of …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is
mainly treated with chemotherapy-based combination therapy. In recent years, with the …

Background An important factor in tumor development and progression is the tumor
microenvironment (TME), which is heterogeneous. Previous studies have mainly …

Tumor microenvironment (TME) is the ecosystem surrounding a tumor to influence tumor
cells' growth, metastasis and immunological battlefield, in which the tumor systems fight …

Simple Summary High-grade serous ovarian cancer (HGSOC) is a highly lethal form of
ovarian carcinoma characterized by molecular heterogeneity. This heterogeneity is a …