Hypoxia is a common feature of the tumor microenvironment, which is characterized by
tissue oxygen deficiency due to an aggressive proliferation of cancer cells. Hypoxia …

Physically triggered systems hold promise for improving drug delivery by enhancing the
controllability of drug accumulation and release, lowering non-specific toxicity, and …

Robust cytotoxic T cell infiltration has proven to be difficult to achieve in solid tumors. We set
out to develop a flexible protocol to efficiently transfect tumor and stromal cells to produce …

Chemo-immunotherapy has gained increasing attention as one of most promising
combination therapy strategies to battle against malignant cancer. In order to achieve a …

Metal complexes are of increasing interest as pharmaceutical agents in cancer diagnostics
and therapeutics, while some of them suffer from issues such as limited water solubility and …

Due to the specific advantages of ultrasound (US) in therapeutic disease treatments, the
unique therapeutic US technology has emerged. In addition to featuring a low‐invasive …

Focused ultrasound is a treatment modality increasingly used for diverse therapeutic
applications, and currently approved for several indications, including prostate cancers and …

Effective drug delivery in brain tumors remains a major challenge in oncology. Although
local hyperthermia and stimuli-responsive delivery systems, such as thermosensitive …

Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and
immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because …

Focused ultrasound (FUS) has recently emerged as a modulator of the tumor
microenvironment, paving the way for FUS to become a safe yet formidable cancer treatment …